(1) Routine monitoring of white cell counts remains controversial, but results of one study showed that close monitoring of white cell counts allowed for earlier detection of agranulocytosis .(2) The latter one leads to agranulocytosis ; hence monitoring blood investigations is necessary.(3) None of the patients on the drug developed agranulocytosis .(4) When reviewers repeated the trial years later, in a larger population, they found the incidence of this agranulocytosis was much lower than previously thought.(5) In the United Kingdom the drug may only be prescribed by registered consultant psychiatrists; this reflects the serious adverse effect profile of the drug, which includes agranulocytosis .
